circRNA basic information
circBase ID: -
Name: hsa_circ_UBE2D2
Synonym: circ-UBE2D2
Host Gene: hsa-miR-376a-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human lung cancer cell lines (A549, H1299, H1650), BEAS-2B cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-376a-3p
Biological function: Circ-UBE2D2 promoted the proliferation, migration and invasion, but repressed apoptosis of NSCLC cells.
Molecular mechanism: circ-UBE2D2 directly targeted hsa-miR-376a-3p and up-regulated hsa-miR-376a-3p restrained proliferation, migration and invasion, but accelerated apoptosis of NSCLC cells. More importantly, EIF4G2 was the target of hsa-miR-376a-3p, and overexpression of EIF4G2 reversed the effects of circ-UBE2D2 downregulation on proliferation, migration, invasion and apoptosis of NSCLC cells.
Survival: -
Supported No.:
 1
Description:

These results suggest that circ-UBE2D2 promotes the proliferation, migration and invasion but restrains apoptosis of lung cancer cells by regulating miR-376a-3p/EIF4G2 axis.
Other information
Title:

Circular RNA-UBE2D2 accelerates the proliferation and metastasis of non-small cell lung cancer cells via modulating microRNA-376a-3p/Eukaryotic Translation Initiation Factor 4gamma2 axis.

Journal: Bioengineered
Published: 2022/2/24
PubMed ID: 35196197