circRNA basic information
circBase ID: -
Name: hsa_circ_TRIO
Synonym: circTRIO
Host Gene: hsa-miR-136-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: interleukin-1beta-treated chondrocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NAMPT
Associated microRNA: hsa-miR-136-5p
Biological function: Knockdown circTRIO facilitates chondrocyte viability, but suppresses the inflammation, the apoptosis, and matrix metalloproteinases (MMP)-3 and MMP-13 expression, whereas up-regulation aggravates OA.
Molecular mechanism: circTRIO competitively adsorbing miR-136-5p to target NAMPT influences OA.
Survival: -
Supported No.:
 2
Description:

The results of this study inform that the circTRIO/miR-136-5p/NAMPT axis is momentous in OA progression and is supposed to be a promising therapeutic target for some time.
Other information
Title:

Circular RNA triple functional domain promotes osteoarthritis development by modulating the microRNA-136-5p/Nicotinamide phosphoribosyltransferase axis.

Journal: Bioengineered
Published: 2022/2/23
PubMed ID: 35191807