circRNA basic information
circBase ID: hsa_circ_0001821
Name: -
Synonym: circ_0001821
Host Gene: hsa-miR-148a-3p
 
 
 
Disease basic information
DO ID:
 3151
DO name: skin squamous cell carcinoma
Disease details: cutaneous squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human epidermal keratinocytes (NHEK), CSCC cell lines (A431, SCL-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-148a-3p
Biological function: circ_0001821 level was increased in CSCC tissues and cells. circ_0001821 knockdown restrained cell viability, colony formation, cell cycle processes, and metastasis, and facilitated cell apoptosis_n vitro, and restrained tumor growth_n vivo.
Molecular mechanism: circ_0001821 directly targeted hsa-miR-148a-3p to elevate EGFR expression.
Survival: -
Supported No.:
 1
Description:

circ_0001821 functioned as a tumor promoter in CSCC via regulating the miR-148a-3p/EGFR axis and PI3K/Akt pathway.
Other information
Title:

circ_0001821 Contributes to the Development of Cutaneous Squamous Cell Carcinoma by Regulating MicroRNA-148a-3p/EGFR Axis and Activating Phosphatidylinositol 3-Kinase/Akt Pathway.

Journal: Mol Cell Biol
Published: 2022/2/23
PubMed ID: 35191745