circRNA basic information
circBase ID: -
Name: hsa_circ_CUL2
Synonym: circCUL2
Host Gene: hsa-miR-203a-5p
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human PDAC cell lines culture (PANC-1, MiaPaCa-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-203a-5p
Biological function: Upregulation of circCUL2 expression in normal fibroblasts (NFs) induced the iCAF phenotype, and then iCAFs promoted PDAC progression through IL6 secretion in vitro. Furthermore, circCUL2-transduced NFs promoted tumorigenesis and metastasis of PDAC cells in vivo, which was blocked by an anti-IL6 antibody.
Molecular mechanism: circCUL2 functioned as a ceRNA and modulated the hsa-miR-203a-3p/MyD88/NF-¦ĘB/IL6 axis, thereby further activating the STAT3 signaling pathway in pancreatic cancer cells to induce PDAC progression.
Survival: poor
Supported No.:
 1
Description:

We showed that the circCUL2/miR-203a-5p/MyD88/NF-¦ĘB/IL6 axis contributes to the induction of iCAFs and established a distinct fibroblast niche for PDAC progression, which could help the development of strategies that selectively target tumor-promoting CAFs in PDAC.
Other information
Title:

circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-kappaB signaling pathway.

Journal: J Exp Clin Cancer Res
Published: 2022/2/23
PubMed ID: 35189958