circRNA basic information
circBase ID: -
Name: hsa_circ_OGDH
Synonym: CircOGDH
Host Gene: hsa-miR-5112
 
 
 
Disease basic information
DO ID:
 2316
DO name: brain ischemia
Disease details: acute ischemic stroke
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Primary cortical neurons
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-5112
Biological function: knockdown of CircOGDH significantly enhanced neuronal cell viability under ischemic conditions.
Molecular mechanism: hsa-miR-5112 by CircOGDH enhanced_OL4A4_xpression to elevate neuron damage.
Survival: -
Supported No.:
 1
Description:

These results demonstrate that CircOGDH is a potential therapeutic target for regulating ischemia neuronal viability, and is enriched in neuron-derived exosomes in the peripheral blood, exhibiting a predictive biomarker of penumbra in patients with AIS.
Other information
Title:

CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke.

Journal: Circ Res
Published: 2022/2/23
PubMed ID: 35189704