circRNA basic information
circBase ID: -
Name: hsa_circ_SOD2
Synonym: CircSOD2
Host Gene: hsa-miR-2355-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal bronchial epithelial cell lines (HBE), human NSCLC lines (HCC827, H1299, H1975, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-2355-5p
Biological function: CircSOD2 suppression impaired lung cancer cell growth, cell migration, prohibited cell cycle progression, and in vivo tumor growth by targeting miR-2355-5p expression in NSCLC tissues.
Molecular mechanism: hsa-miR-2355-5p binds to the CircSOD2 promoter and triggered its stimulation, which further activated circSOD2 expression.
Survival: -
Supported No.:
 1
Description:

This innovative signaling axis CircSOD2/miR-2355-5p/CAMSAP2 illustrated the new horizon to investigate NSCLC tumorigenesis and provided new prognosis and treatment of NSCLC.
Other information
Title:

CircRNA SOD2 motivates non-small cell lungs cancer advancement with EMT via acting as microRNA-2355-5p competing endogenous RNA to mediate calmodulin regulated spectrin associated proteins-2.

Journal: Bioengineered
Published: 2022/2/22
PubMed ID: 35188072