circRNA basic information
circBase ID: -
Name: hsa_circ_PIP5K1A
Synonym: circPIP5K1A
Host Gene: hsa-miR-552-3p
 
 
 
Disease basic information
DO ID:
 9352
DO name: type 2 diabetes mellitus
Disease details: type 2 diabetes
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: INS-1E cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: JAK1
Associated microRNA: hsa-miR-552-3p
Biological function: reduced expression ofcircPIP5K1A leads to decreased rate of inflammation, oxidative damage and apoptosisinINS-1E cells induced by glucolipotoxicity.
Molecular mechanism: CircPIP5K1A was available to competitively combine with miR-552-3p, while whose direct target was JAK1.
Survival: -
Supported No.:
 1
Description:

our study suggested a novel involvement of circPIP5K1A in a cross talk between miR5523p/JAK1/STAT3 pathways in beta-cells as a new therapeutic target for T2DM.
Other information
Title:

Circular RNA PIP5K1A act as microRNA-552-3p sponge to regulates inflammation, oxidative damage in glucolipotoxicity-induced pancreatic INS-1 beta-cells via Janus kinase 1.

Journal: Bioengineered
Published: 2022/2/22
PubMed ID: 35184688