circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_101093
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human LUAD cell lines (H1650, PC9, H1975, H358, A549, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: exosomal circRNA_101093 (cir93) maintained an elevation in intracellular cir93 in LUAD to modulate AA, a poly-unsaturated fatty acid critical for ferroptosis-associated increased peroxidation in the plasma membrane.
Molecular mechanism: cir93 interacted with and increased fatty acid-binding protein 3 (FABP3), which transported AA and facilitated its reaction with taurine.
Survival: -
Supported No.:
 1
Description:

Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis, and blocking exosome may be helpful for future LUAD treatment.
Other information
Title:

Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma.

Journal: Cancer Commun (Lond)
Published: 2022/2/21
PubMed ID: 35184419