circRNA basic information
circBase ID: hsa_circ_0006873
Name: -
Synonym: Circ_0006873
Host Gene: hsa-miR-142-5p
 
 
 
Disease basic information
DO ID:
 11476
DO name: osteoporosis
Disease details: osteoporosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human bone mesenchymal stem cells (hBMSCs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-142-5p
Biological function: Following experiments revealed that cell viability, proliferation-related factors, osteogenic marker genes (ALP, Runx2, Bglap) and osteoblastic differentiation degree were promoted after circ_0006873 knockdown but inhibited after overexpression.
Molecular mechanism: circ_0006873 can negatively target hsa-miR-142-5p via regulating PTEN
Survival: -
Supported No.:
 1
Description:

Circ_0006873 sponges miR-142-5p thereby enhances PTEN expression to suppress osteoblastic differentiation via regulation of Akt signaling pathway, thus, may provide a treatment approach for osteoporosis.
Other information
Title:

Circ_0006873 Sponges miR-142-5p to Inhibit Osteoblastic Differentiation of hBMSCs via Regulating PTEN/Akt Signaling Pathway.

Journal: Ann Clin Lab Sci
Published: 2022/2/20
PubMed ID: 35181618