circRNA basic information
circBase ID: hsa_circ_0061587
Name: -
Synonym: circ_0061587
Host Gene: hsa-miR-485-5p
 
 
 
Disease basic information
DO ID:
 111253
DO name: neurofibromatosis 1
Disease details: neurofibromatosis type 1
Species: human
Species details: human
Sample type: cell line
Sample type details: human NF1-associated MPNST cell lines (ST88_14, T265p21) along with non-NF1-associated MPNST cell line (STS26T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-485-5p
Biological function: he results of loss-of-function assays revealed that silencing of circ_0061,587 hampered the proliferation, migration, and invasion but stimulated the apoptosis of human NF1-associated MPNST cells.
Molecular mechanism: circ_0061,587 sequestered microRNA-485-5p (hsa-miR-485-5p) to modulate the expression of RUNX family transcription factor 1 (RUNX1) and annexin A11 (ANXA11).
Survival: -
Supported No.:
 1
Description:

In conclusion, circ_0061,587 functioned as an oncogene in NF1-associated MPNST cells and this study might provide novel insights for the diagnosis and treatment of NF1.
Other information
Title:

Circular RNA_0061587 is associated with the tumorigenesis of neurofibromatosis type 1.

Journal: Neurochem Int
Published: 2022/2/20
PubMed ID: 35181394