circRNA basic information
circBase ID: hsa_circ_0067934
Name: -
Synonym: Circ_0067934
Host Gene: hsa-miR-545-3p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal ovarian epithelial cell line (IOSE80, OC cell lines A2780 , SKOV3 , ES2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-545-3p
Biological function: Downregulation of circ_0067934 reduced DDP resistance of the DDP-resistant A2780/DDP cell line and reduced cell proliferation and invasion, but the malignant behaviors of OC cells were restored after further miR-545-3p downregulation.
Molecular mechanism: Circ_0067934 served as a sponge for hsa-miR-545-3p and diminished its suppressive effect on PPA1 translation.
Survival: -
Supported No.:
 1
Description:

This study suggests that circ_0067934 sequesters miR-545-3p and enhances PPA1 expression to promote tumorigenesis and DDP resistance in OC. This study may provide novel approaches in the management of OC.
Other information
Title:

Circ_0067934 reduces JNK phosphorylation through a microRNA-545-3p/PPA1 axis to enhance tumorigenesis and cisplatin resistance in ovarian cancer.

Journal: Immunopharmacol Immunotoxicol
Published: 2022/2/19
PubMed ID: 35179434