circRNA basic information
circBase ID: hsa_circ_0000190
Name: -
Synonym: circ_0000190
Host Gene: hsa-miR-301a
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: multiple myeloma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MM cell lines (RPMI-8226, NCI-H929, OPM-2, LP-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-301a
Biological function: circ_0000190 overexpression promoted MM cell cycle arrest and apoptosis but restrained the ability of migration and invasion.
Molecular mechanism: hsa-miR-301a was identified as a target of circ_0000190, and hsa-miR-301a reintroduction largely abolished the effects of circ_0000190 overexpression. The activation of JAK1/STAT3 pathway was promoted by hsa-miR-301a restoration.
Survival: -
Supported No.:
 2
Description:

This study enhanced the understanding of the mechanism of Icaritin associated with circRNAs in MM.
Other information
Title:

Icaritin-elevated circ_0000190 suppresses the malignant progression of multiple myeloma by targeting miR-301a.

Journal: Kaohsiung J Med Sci
Published: 2022/2/18
PubMed ID: 35174633