circRNA basic information
circBase ID: -
Name: hsa_circ_AFAP1
Synonym: Circ-AFAP1
Host Gene: hsa-miR-374b-3p
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: 786-O, A498
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-374b-3p
Biological function: circAFAP1 contributed to ccRCC angiogenesis.
Molecular mechanism: hsa-miR-374b-3p or overexpression VEGFA could restore proliferation, vascular formation after circAFAP1 silencing.
Survival: -
Supported No.:
 1
Description:

In conclusion, the circAFAP1/miR-374b-3p/VEGFA axis played a critical role in the progression and development of ccRCC which might be novel biological marks and therapeutical targets.
Other information
Title:

Circ-AFAP1 promote clear cell renal cell carcinoma growth and angiogenesis by the Circ-AFAP1/miR-374b-3p/VEGFA signaling axis.

Journal: Cell Death Discov
Published: 2022/2/18
PubMed ID: 35173146