circRNA basic information
circBase ID: -
Name: hsa_circ_VMA21
Synonym: circVMA21
Host Gene: hsa-miR-497-5p
 
 
 
Disease basic information
DO ID:
 0040085
DO name: bacterial sepsis
Disease details: sepsis
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: Maintaining of human lung epithelial cell line BEAS-2B
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-497-5p
Biological function: Overexpression of circVMA21 ameliorated these phenomena. In addition, LPS-induced apoptosis and inflammation of BEAS-2B cells was improved via overexpression of circVMA21.
Molecular mechanism: CircVMA21 mediated CD2AP expression through competitive adsorption of hsa-miR-497-5p.
Survival: -
Supported No.:
 2
Description:

In conclusion, this work showed circVMA21 improved LI in sepsis rats by targeting miR-497-5p/CD2AP axis, suggesting that circVMA21 may be a novel therapeutic target for sepsis-induced LI.
Other information
Title:

Circular RNA VMA21 ameliorates lung injury in septic rat via targeting microRNA-497-5p/CD2-associated protein axis.

Journal: Bioengineered
Published: 2022/2/18
PubMed ID: 35172672