circRNA basic information
circBase ID: hsa_circ_0008365
Name: -
Synonym: circ_0008365
Host Gene: hsa-miR-324-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: cell line
Sample type details: chondrocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BMPR2
Associated microRNA: hsa-miR-324-5p
Biological function: circ_0008365 overexpression partly relieved IL-1beta-induced cell damage in chondrocytes.
Molecular mechanism: Circ_0008365 could interact with miR-324-5p, and BMPR2 was a downstream target of miR-324-5p.
Survival: -
Supported No.:
 2
Description:

Circ_0008365 reduced IL-1beta-induced cell damage in chondrocytes via inactivating NF-¦ĘB signaling pathway and regulating miR-324-5p/BMPR2 axis.
Other information
Title:

Circ_0008365 Suppresses Apoptosis, Inflammation and Extracellular Matrix Degradation of IL-1beta-treated Chondrocytes in Osteoarthritis by Regulating miR-324-5p/BMPR2/NF-kappaB Signaling Axis.

Journal: Immunol Invest
Published: 2022/2/18
PubMed ID: 35172669