circRNA basic information
circBase ID: -
Name: hsa_circ_Plekha7
Synonym: circPlekha7
Host Gene: hsa-miR-493-3p
 
 
 
Disease basic information
DO ID:
 0050855
DO name: renal fibrosis
Disease details: renal fibrosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: cell line (no. BNCC340460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-493-3p
Biological function: Overexpression of circPlekha7 or knockdown of miR-493-3p suppressed TGF-beta1 induced enhancements on epithelial to mesenchymal transition and fibrogenesis, as well as attenuated renal fibrosis and injury in mice subjected to unilateral ureteral obstruction.
Molecular mechanism: circPlekha7 bound with hsa-miR-493-3p, which directly targeted KLF4.
Survival: -
Supported No.:
 1
Description:

circPlekha7 inhibits epithelial to mesenchymal transition of renal tubular epithelial cells and fibrosis via targeting miR-493-3p to de-repress KLF4/mitofusin2 expression.
Other information
Title:

circPlekha7 suppresses renal fibrosis via targeting miR-493-3p/KLF4.

Journal: Epigenomics
Published: 2022/2/18
PubMed ID: 35172608