circRNA basic information
circBase ID: -
Name: hsa_circ_CDK17
Synonym: CircCDK17
Host Gene: hsa-miR-1294
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CC cell lines (C-33A, HeLa), human cervical epithelial cell line (Ect1/E6E7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1294
Biological function: CircCDK17 silencing suppressed cell proliferation, migration, invasion and glycolysis, and induced cell apoptosis in CC;
Molecular mechanism: circCDK17 was a sponge of hsa-miR-1294 and hsa-miR-1294 bound to YWHAZ.
Survival: -
Supported No.:
 4
Description:

CircCDK17 knockdown repressed cell proliferation, migration, invasion and glycolysis, and promoted cell apoptosis via miR-1294/YWHAZ axis in CC. This finding provides a theoretical basis in studying circRNA-mediated therapy in CC.
Other information
Title:

CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer.

Journal: J Ovarian Res
Published: 2022/2/17
PubMed ID: 35168653