circRNA basic information
circBase ID: hsa_circ_0068464
Name: -
Synonym: circ_0068464
Host Gene: hsa-miR-383
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SW480, SW620, HT29, LS174T, HCT11
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-383
Biological function: Knockdown of circ_0068464 could inhibit CRC cell migration and proliferation and promoted apoptosis .tumorigenic assays in nude mice confirmed that circ_0068464 downregulation significantly inhibited tumor growth and lung metastasis.
Molecular mechanism: circ_0068464 targets hsa-miR-383 to regulate Wnt/beta-catenin pathway activation, thereby promoting the development of CRC.
Survival: -
Supported No.:
 1
Description:

circ_0068464 targets miR-383 to regulate Wnt/beta-catenin pathway activation, thereby promoting the development of CRC.
Other information
Title:

Circular RNA circ_0068464 combined with microRNA-383 regulates Wnt/beta-catenin pathway to promote the progression of colorectal cancer.

Journal: Bioengineered
Published: 2022/2/17
PubMed ID: 35168468