circRNA basic information
circBase ID: mmu_circ_0000943
Name: -
Synonym: -
Host Gene: mmu-miR-377-3p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: mouse
Species details: mouse
Sample type: cell line, PDX
Sample type details: mouse kindey proximal tubule cell
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: Egr2
Associated microRNA: mmu-miR-377-3p
Biological function: Knockdown of mmu_circ_0000943 inhibited cell apoptosis, inflammatory cytokine expression and oxidative stress upon H/R treatment.
Molecular mechanism: co-transfection of siRNA targeting mmu_circ_0000943 and miR-377-3p inhibitor could counteract the anti-IRI effect. Furthermore, mmu_circ_0000943 regulated the expression of Egr2 by sponging miR-377-3p to alleviate H/R-induced TKPTS cell damage.
Survival: -
Supported No.:
 1
Description:

This study suggested that mmu_circ_0000943 participated in progression of renal IRI by sponging miR-377-3p with Egr2, providing a new insight into AKI treatment.
Other information
Title:

Downregulation of mmu_circ_0000943 ameliorates renal ischemia reperfusion-triggered inflammation and oxidative stress via regulating mmu-miR-377-3p/Egr2 axis.

Journal: Int Immunopharmacol
Published: 2022/2/16
PubMed ID: 35168080