circRNA basic information
circBase ID: -
Name: hsa_circ_LPAR1
Synonym: circLPAR1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: FHC, HCT116, DLD1 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: exosomal circLPAR1 was internalized by CRC cells, and it suppressed tumor growth
Molecular mechanism: exosomal circLPAR1 directly bound with eIF3h specifically suppressed the METTL3-eIF3h interaction, decreasing the translation of oncogene BRD4.
Survival: -
Supported No.:
 1
Description:

This comprehensive study highlights plasma exosomal circLPAR1 as a promising predictor in CRC diagnosis and describes its biological regulation of colorectal tumorigenesis. This study provides a new perspective on early diagnosis in the clinic and pathogenesis in disease development.
Other information
Title:

Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3-eIF3h interaction.

Journal: Mol Cancer
Published: 2022/2/16
PubMed ID: 35164758