circRNA basic information
circBase ID: -
Name: hsa_circ_MMD
Synonym: CircMMD_007
Host Gene: hsa-miR-197-3p
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal cell line (LC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-197-3p
Biological function: The expression of circMMD_007 was higher in advanced stages. Knockout of circMMD_007 hindered the tumorigenesis of LC in vivo and in vitro.
Molecular mechanism: circMMD_007 could negatively regulate the expression of hsa-miR-197-3p. PTPN9 behaved to be a molecular target of hsa-miR-197-3p.
Survival: -
Supported No.:
 1
Description:

In summary, this research demonstrated that circular RNA circMMD_007 could promote the oncogenic effects in the progression of LC through miR-197-3p/PTPN9 axis.
Other information
Title:

CircMMD_007 promotes oncogenic effects in the progression of lung adenocarcinoma through microRNA-197-3p/protein tyrosine phosphatase non-receptor type 9 axis.

Journal: Bioengineered
Published: 2022/2/15
PubMed ID: 35156900