circRNA basic information
circBase ID: -
Name: hsa_circ_FOXO3
Synonym: circRNA_FOXO3
Host Gene: hsa-miR-23a
 
 
 
Disease basic information
DO ID:
 0040085
DO name: bacterial sepsis
Disease details: ICU-acquired sepsis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-23a
Biological function: LPS-induced cell viability loss and dysregulation of cytokines were effectively restored by the knockdown of FOXO3 or circRNA_FOXO3 siRNA in the cells.
Molecular mechanism: The expression of circRNA_FOXO3 was found to be positively associated with the expression of Forkhead Box O3 (FOXO3), which is targeted and regulated by hsa-miR-23a.
Survival: -
Supported No.:
 1
Description:

This study revealed that the minor allele of rs12196996 polymorphism and rs2232365 polymorphism collaboratively contributed to the increased survival and suppressed severity of ICU-acquired sepsis.
Other information
Title:

Effect of circRNA_FOXO3 rs12196996 polymorphism and FOXO3 rs2232365 polymorphism on survival rate and severity of intensive care unit-acquired sepsis.

Journal: Bioengineered
Published: 2022/2/15
PubMed ID: 35156517