circRNA basic information
circBase ID: -
Name: hsa_circ_CLK1
Synonym: Circ-CLK1
Host Gene: hsa-miR-18b-5p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: OSCC cell lines (UM1, HSC-2), normal human oral epithelial cell lines (SG)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-18b-5p
Biological function: Inhibition of circ-CLK1 reduced the viability and proliferation of OSCC cells while enhancing their apoptosis
Molecular mechanism: inhibiting hsa-miR-18b-5p or overexpression of Y-box protein 2 (YBX2) can reverse the effect of circ-CLK1 knockdown on OSCC cells.
Survival: -
Supported No.:
 1
Description:

Therefore, circ-CLK1 inhibited the apoptosis of OSCC cells through the miR-18b-5p/YBX2 axis, and these findings suggest that circ-CLK1 could be a potential therapeutic target for OSCC patients.
Other information
Title:

Circular CDC like kinase 1 suppresses cell apoptosis through miR-18b-5p/Y-box protein 2 axis in oral squamous cell carcinoma.

Journal: Bioengineered
Published: 2022/2/15
PubMed ID: 35156507