circRNA basic information
circBase ID: hsa_circ_0001326
Name: -
Synonym: -
Host Gene: hsa-miR-136-5p
 
 
 
Disease basic information
DO ID:
 2841
DO name: asthma
Disease details: Asthma
Species: human
Species details: human
Sample type: cell line
Sample type details: THP-1 derived macrophages
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: USP4
Associated microRNA: hsa-miR-136-5p
Biological function: hsa_circ_0001326 expression was upregulated in luteolin treat THP-1 derived macrophages. Silence of hsa_circ_0001326 reversed the function of luteolin on macrophages polarization.
Molecular mechanism: hsa_circ_0001326 attenuated the inhibition effect of luteolin on hsa-miR-136-5p expression, and the promotion effect on USP4 expression.
Survival: -
Supported No.:
 1
Description:

These findings provide a new insight for macrophage polarization under stimulation of luteolin.
Other information
Title:

Luteolin activates M2 macrophages and suppresses M1 macrophages by upregulation of hsa_circ_0001326 in THP-1 derived macrophages.

Journal: Bioengineered
Published: 2022/2/15
PubMed ID: 35152837