circRNA basic information
circBase ID: -
Name: hsa_circ_RHOBTB3
Synonym: circRHOBTB3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human osteoblasts (hFOB), osteosarcoma cell lines (U2OS, SaoS-2, HOS)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circRHOBTB3 acts a tumor-suppressive circRNA by repressing metabolic pathways, intracellular ROS production in CRC. Several key elements were discovered to regulate circRHOBTB3 circularization and exosomal secretion.
Molecular mechanism: -
Survival: poor
Supported No.:
 3
Description:

circRHOBTB3 plays a tumor-suppressive role in CRC and has to be excreted out of cells to sustain cancer cell fitness. ASOs targeting regulatory elements for circularization and exosomal secretion will become a novel antitumor strategy.
Other information
Title:

Tumor-suppressive circRHOBTB3 is excreted out of cells via exosome to sustain colorectal cancer cell fitness.

Journal: Mol Cancer
Published: 2022/2/13
PubMed ID: 35148775