circRNA basic information
circBase ID: -
Name: hsa_circ_TAOK1
Synonym: circTAOK1
Host Gene: hsa-miR-520h
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic kidney disease
Species: human
Species details: human
Sample type: cell line
Sample type details: human glomerular epithelial cells (GEC, Cat: YBH1049, YBio, Shanghai, China), glomerular mesangial cells (GMC, Cat: CL-H067, Procell, Wuhan, China)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-520h
Biological function: GEC-circTAOK1-Exo could promote proliferation, fibrosis, and epithelial_mesenchymal transition (EMT) of glomerular mesangial cells (GMCs)
Molecular mechanism: circTAOK1 could regulate SMAD3 expression by sponging hsa-miR-520h, GEO-si-circTAOK1 Exo-induced hsa-miR-520h and repressed SMAD3 expression in GMC.
Survival: -
Supported No.:
 3
Description:

GEC-circTAOK1-Exo could boost proliferation, fibrosis, and EMT of GMC through targeting the miR-520h/SMAD3 axis, providing new insights into the pathogenesis of DN.
Other information
Title:

Exosomal circTAOK1 contributes to diabetic kidney disease progression through regulating SMAD3 expression by sponging miR-520h.

Journal: Int Urol Nephrol
Published: 2022/2/11
PubMed ID: 35142978