circRNA basic information
circBase ID: -
Name: hsa_circ_VMA21
Synonym: circVMA21
Host Gene: hsa-miR-103
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human chondrocyte cell line (CHON-001)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-103
Biological function: VMA21 could be detected in both nuclear and cytoplasm
Molecular mechanism: VMA21 directly interacted with pre-hsa-miR-103. VMA21 overexpression reduced hsa-miR-103 maturation. VMA21 suppressed the role of hsa-miR-103 in enhancing chondrocyte apoptosis and reducing cell viability after LPS treatment.
Survival: -
Supported No.:
 1
Description:

In conclusion, VMA21 might suppress LPS-induced chondrocyte apoptosis in OA by decreasing the production of mature miR-103.
Other information
Title:

Circular RNA Derived from Vacuolar ATPase Assembly Factor VMA21 Suppresses Lipopolysaccharide-Induced Apoptosis of Chondrocytes in Osteoarthritis (OA) by Decreasing Mature miR-103 Production.

Journal: Mol Biotechnol
Published: 2022/2/10
PubMed ID: 35138580