circRNA basic information
circBase ID: -
Name: hsa_circ_CHFR
Synonym: circCHFR
Host Gene: hsa-miR-15b-5p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HUVECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-15b-5p
Biological function: circCHFR silencing significantly improved viability and reduced apoptosis of HUVECs.
Molecular mechanism: circCHFR serves as a molecular sponge of hsa-miR-15b-5p. GADD45G was found to be an important target of hsa-miR-15b-5p
Survival: -
Supported No.:
 6
Description:

In conclusion, circCHFR promotes atherosclerosis progression via the miR-15b-5p/GADD45G axis and may be an important target for atherosclerosis treatment.
Other information
Title:

Circular RNA circCHFR downregulation protects against oxidized low-density lipoprotein-induced endothelial injury via regulation of microRNA-15b-5p/growth arrest and DNA damage inducible gamma.

Journal: Bioengineered
Published: 2022/2/10
PubMed ID: 35137664