circRNA basic information
circBase ID: hsa_circ_0004015
Name: -
Synonym: Circ_0004015
Host Gene: hsa-miR-198
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human bronchial epithelial cell line (16HBE), NSCLC cells (A549, H1299) as well as DDP-resistant A549 (A549/DDP) cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-198
Biological function: circ_0004015 silencing repressed DDP resistance, cell proliferation, migration and invasion, but induced cell apoptosis in DDP-resistant NSCLC cells._irc_0004015 knockdown promoted the effect of DDP on tumor formation in vivo.
Molecular mechanism: hsa-miR-198 inhibitors attenuated circ_0004015 depletion-mediated action though associating with circ_0004015. hsa-miR-198 regulated DDP sensitivity and NSCLC progression by targeting KLF8.
Survival: -
Supported No.:
 2
Description:

Circ_0004015 conferred DDP resistance and promoted NSCLC progression by miR-198/KLF8 pathway, proving a potential target for studying DDP-mediated treatment of NSCLC.
Other information
Title:

Circ_0004015 silencing represses cisplatin chemoresistance and tumor progression by reducing KLF8 in a miR-198-dependent manner in non-small cell lung cancer.

Journal: Genomics
Published: 2022/2/9
PubMed ID: 35134495