circRNA basic information
circBase ID: -
Name: hsa_circ_PRMT5
Synonym: circPRMT5
Host Gene: -
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: bladder cancer (T24)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: The results showed that SCNTs/si-circPRMT5 nanomaterials prolong si-circPRMT5s half-life in circulation, enhance its specific uptake by tumor cells, and maximize the silencing efficiency of circPRMT5. I
Molecular mechanism: Mechanistic study showed that SCNTs/si-circPRMT5 regulated the hsa-miR-30c/SNAIL1/E-cadherin axis, inhibiting bladder cancer growth and progression.
Survival: -
Supported No.:
 1
Description:

The results highlight the potential therapeutic utility of SCNTs/si-circPRMT5 to deliver si-circPRMT5 to treat bladder cancer.
Other information
Title:

Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA.

Journal: Biomater Res
Published: 2022/2/7
PubMed ID: 35123588