circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF652
Synonym: CircZNF652
Host Gene: hsa-miR-452-5p
 
 
 
Disease basic information
DO ID:
 0080817
DO name: T2-high asthma
Disease details: goblet cell metaplasia of asthma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: 16HBE
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-452-5p
Biological function: circZNF652 promoted the goblet cell metaplasia
Molecular mechanism: circZNF652 promoted the goblet cell metaplasia by functioning as a sponge of hsa-miR-452-5p, which released the Janus kinase 2 (JAK2) expression and subsequently activated JAK2/signal transducer and activator of transcription 6 (STAT6) signaling in the allergic airway epithelia.
Survival: -
Supported No.:
 1
Description:

Upregulation of circZNF652 expression in allergic bronchial epithelia contributed to the goblet cell metaplasia by activating the miR-452-5p/JAK2/STAT6 signaling pathway; thus, blockage of circZNF652 or agonism of miR-452-5p provided an alternative approach for the therapeutic intervention of epithelial remodeling in allergic airway inflammation.
Other information
Title:

CircZNF652 promotes the goblet cell metaplasia by targeting the miR-452-5p/JAK2 signaling pathway in allergic airway epithelia.

Journal: J Allergy Clin Immunol
Published: 2022/2/6
PubMed ID: 35120971