circRNA basic information
circBase ID: -
Name: hsa_circ_PLK1
Synonym: circPLK1
Host Gene: hsa-miR-1294
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CALU3, CALU6, A549, H1229, H1975 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1294
Biological function: The overexpression of circPLK1 also promotes the malignant phenotype of NSCLC cells.
Molecular mechanism: circPLK1 directly targets hsa-miR-1294 and negatively regulates its activity
Survival: poor
Supported No.:
 1
Description:

Our study suggests that circPLK1 upregulation plays an important role in NSCLC progression by targeting miR-1294/HMGA1 axis. These data provide a theoretical basis for the development of therapeutic strategy targeting exosomal circPLK1 in NSCLC treatment.
Other information
Title:

Upregulation of exosomal circPLK1 promotes the development of non-small cell lung cancer through the miR-1294/ high mobility group protein A1 axis.

Journal: Bioengineered
Published: 2022/2/5
PubMed ID: 35114891