circRNA basic information
circBase ID: -
Name: hsa_circ_TMOD3
Synonym: circTMOD3
Host Gene: hsa-miR-27a
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-27a
Biological function: CircTMOD3 directly interacted with premature miR-27a and promoted LPS-induced chondrocyte apoptosis, while miR-27a inhibited LPS-induced chondrocyte apoptosis.
Molecular mechanism: circTMOD3 overexpression suppressed miR-27a maturation and reduced the inhibitory effects of miR-27a on LPS-induced chondrocyte apoptosis.
Survival: -
Supported No.:
 1
Description:

CircTMOD3 suppresses miR-27a maturation in OA to promote chondrocyte apoptosis induced by LPS.
Other information
Title:

CircTMOD3 promotes lipopolysaccharide-induced chondrocyte apoptosis in osteoarthritis by sponging miR-27a.

Journal: J Bone Miner Metab
Published: 2022/2/2
PubMed ID: 35103839