circRNA basic information
circBase ID: hsa_circ_0002577
Name: -
Synonym: Circ_0002577
Host Gene: hsa-miR-126-5p
 
 
 
Disease basic information
DO ID:
 1380
DO name: endometrial cancer
Disease details: endometrial cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human endometrial stromal cells (hESC), EC cells (HEC-1B, KLE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-126-5p
Biological function: Loss-of-functional experiment revealed that silencing of circ_0002577 inhibited the proliferation, migration, and invasion while induced apoptosis of EC cells
Molecular mechanism: The upregulation of hsa-miR-126-5p also impeded proliferation and mobility while induced apoptosis of EC cells. hsa-miR-126-5p, negatively regulating MACC1 expression, was a functional target of circ_0002577 in EC cells.
Survival: -
Supported No.:
 4
Description:

The contributions of the circ_0002577 in EC were contributed to its interactions with miR-126-5p and MACC1, which offered a new perspective to the roles of circ_0002577 in EC.
Other information
Title:

Circ_0002577/miR-126-5p/MACC1 axis promotes endometrial carcinoma progression by regulation of proliferation, migration, invasion, and apoptosis of endometrial carcinoma cells.

Journal: Arch Gynecol Obstet
Published: 2022/2/2
PubMed ID: 35103833