circRNA basic information
circBase ID: -
Name: hsa_circ_CSPP1
Synonym: circCSPP1
Host Gene: hsa-miR-431
 
 
 
Disease basic information
DO ID:
 219
DO name: colon cancer
Disease details: colon cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SW620, SW480, LOVO, HCT116 ,DLD-1 cells, THP-1 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-431
Biological function: Overexpression of circCSPP1 significantly promoted the proliferation, migration and invasion of colon cancer cells
Molecular mechanism: circCSPP1 was found to bind with hsa-miR-431. In addition, ROCK1 and ZEB1 were identified as the target genes of hsa-miR-431.
Survival: -
Supported No.:
 1
Description:

Taken together, the findings of the present study indicated that circCSPP1 may function as a competing endogenous RNA in the progression of colon cancer by regulating the miR-431/ROCK1 and miR-431/ZEB1 signaling axes.
Other information
Title:

Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1.

Journal: J Transl Med
Published: 2022/2/2
PubMed ID: 35101080