circRNA basic information
circBase ID: -
Name: hsa_circ_SWT1
Synonym: Circ-SWT1
Host Gene: hsa-miR-192-5p
 
 
 
Disease basic information
DO ID:
 9408
DO name: acute myocardial infarction
Disease details: acute myocardial Infarction
Species: human
Species details: human
Sample type: cell line
Sample type details: human cardiomyocytes AC16 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-192-5p
Biological function: ectopic expression of circ-SWT1 attenuated H2O2-triggered apoptosis, oxidative stress and endoplasmic reticulum (ER) stress in cardiomyocytes in vitro.
Molecular mechanism: circ-SWT1 competitively bound to hsa-miR-192-5p to relieve the repression of hsa-miR-192-5p on its target SOD2.
Survival: -
Supported No.:
 1
Description:

Circ-SWT1 ameliorates H2O2-induced apoptosis, oxidative stress and ER stress in cardiomyocytes via miR-192-5p/SOD2 axis, suggesting the potential involvement of circ-SWT1 in AMI process.
Other information
Title:

Circ-SWT1 Ameliorates H(2)O(2)-Induced Apoptosis, Oxidative Stress and Endoplasmic Reticulum Stress in Cardiomyocytes via miR-192-5p/SOD2 Axis.

Journal: Cardiovasc Toxicol
Published: 2022/2/1
PubMed ID: 35099761