circRNA basic information
circBase ID: -
Name: hsa_circ_DIDO1
Synonym: circDIDO1
Host Gene: hsa-miR-141-3p
 
 
 
Disease basic information
DO ID:
 409
DO name: liver disease
Disease details: liver failure
Species: human
Species details: human
Sample type: cell line
Sample type details: human HSC cell line (LX2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-141-3p
Biological function: CircDIDO1 overexpression or miR-141-3p inhibition suppressed the proliferation, reduced pro-fibrotic markers, and induced apoptosis as well as cell cycle arrest in hepatic stellate cells (HSCs) by blocking PTEN/AKT pathway.
Molecular mechanism: circDIDO1 acted as an endogenous sponge for hsa-miR-141-3p, further rescue experiments showed that circDIDO1 suppressed HSC activation by targeting hsa-miR-141-3p.
Survival: -
Supported No.:
 1
Description:

Clinically, low levels of serum circDIDO1 in exosome were correlated with liver failure, and serum exosomal circDIDO1 had a well diagnostic value for liver fibrosis in liver failure patients. Transfer of circDIDO1 mediated by MSC-isolated exosomes suppressed HSC activation through the miR-141-3p/PTEN/AKT pathway, gaining a new insight into the prevention of liver fibrosis in liver failure patients.
Other information
Title:

Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis.

Journal: Drug Deliv
Published: 2022/2/1
PubMed ID: 35099348