circRNA basic information
circBase ID: -
Name: hsa_circ_SLC8A1
Synonym: circSLC8A1
Host Gene: hsa-miR-214-5p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal glial cell line (HEB), glioma cell lines (U251MG, U87MG, SHG44, T98G)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-214-5p
Biological function: circSLC8A1 inhibits the cell proliferation and invasion of glioma cells.
Molecular mechanism: ircSLC8A1 directly sponged hsa-miR-214-5p and inhibited hsa-miR-214-5p expression in glioma cells. CDC27 was a direct target of hsa-miR-214-5p and could be regulated by hsa-miR-214-5p.
Survival: -
Supported No.:
 1
Description:

Taken together, our results demonstrated a tumor suppressive role of circSLC8A1 in glioma through regulation of glioma cells proliferation and invasion. The effects of circSLC8A1 were mediated by miR-214-5p/CDC27 axis. Our study provided a new understanding of the occurrence and development of gliom.
Other information
Title:

Circular RNA circSLC8A1 inhibits the proliferation and invasion of glioma cells through targeting the miR-214-5p/CDC27 axis.

Journal: Metab Brain Dis
Published: 2022/2/1
PubMed ID: 35098413