circRNA basic information
circBase ID: -
Name: hsa_circ_ADAM9
Synonym: circ-ADAM9
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 8947
DO name: diabetic retinopathy
Disease details: diabetic retinopathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: RPE cells (ARPE-19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CARM1
Associated microRNA: hsa-miR-338-3p
Biological function: Silenced circ-ADAM9 could promote proliferation and inhibit inflammation, apoptosis, and oxidative stress in HG-induced ARPE9 cells.
Molecular mechanism: circ-ADAM9 could sponge miR-338-3p to upregulate CARM1.
Survival: -
Supported No.:
 1
Description:

Circ-ADAM9 contributed to HG-induced ARPE9 cell injury by regulating miR-338-3p/CARM1 axis, which provided effective targets for DR treatment.
Other information
Title:

Circ-ADAM9 Promotes High Glucose-Induced Retinal Pigment Epithelial Cell Injury in DR via Regulating miR-338-3p/CARM1 Axis.

Journal: J Ophthalmol
Published: 2022/2/1
PubMed ID: 35096421