circRNA basic information
circBase ID: -
Name: hsa_circ_LARP1B
Synonym: Circ-LARP1B
Host Gene: hsa-miR-578
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human HCC cell lines (MHCC97, Hep3B, Huh-7), human normal liver epithelial cells (THLE-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-578
Biological function: Functional experiments demonstrated that circ-LARP1B silencing impaired cell proliferation, invasion, angiogenesis and reduced radioresistance in vitro.
Molecular mechanism: circ-LARP1B could competitively bind with hsa-miR-578 to relieve the repression of hsa-miR-578 on the expression of its target gene IGF1R.
Survival: poor
Supported No.:
 2
Description:

Circ-LARP1B knockdown restrained HCC tumorigenicity and enhanced radiosensitivity by regulating miR-578/IGF1R axis, providing a new target for the treatment of HCC.
Other information
Title:

Circ-LARP1B knockdown restrains the tumorigenicity and enhances radiosensitivity by regulating miR-578/IGF1R axis in hepatocellular carcinoma.

Journal: Ann Hepatol
Published: 2022/1/31
PubMed ID: 35093599