circRNA basic information
circBase ID: hsa_circ_0011385
Name: -
Synonym: Circ_0011385
Host Gene: hsa-miR-330-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CRC cell lines (SW480, SW620, LOVO, HCT116), human normal colonic epithelial cell line (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-330-3p
Biological function: Circ_0011385 silencing or MYO6 absence repressed cell proliferation, migration and invasion, whereas induced cell apoptosis in CRC.
Molecular mechanism: Circ_0011385 was associated with hsa-miR-330-3p, and hsa-miR-330-3p targeted MYO6.
Survival: poor
Supported No.:
 1
Description:

Circ_0011385 regulated CRC process by miR-330-3p/MYO6 axis through MEK1/2/ERK1/2 signaling pathway, providing a novel therapeutic target for CRC.
Other information
Title:

Circ_0011385 knockdown inhibits cell proliferation, migration and invasion, whereas promotes cell apoptosis by regulating miR-330-3p/MYO6 axis in colorectal cancer.

Journal: Biomed J
Published: 2022/1/30
PubMed ID: 35091088