circRNA basic information
circBase ID: -
Name: hsa_circ_ZCCHC6
Synonym: circZCCHC6
Host Gene: hsa-miR-433-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Normal human bronchial epithelial cell line (BEAS-2B), NSCLC cell lines (A549, H522, H1975, HCC827), NSCLC cell line (PC-9)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-433-3p
Biological function: circZCCHC6 knockdown could repress cell viability, cell cycle progression, migration, invasion, and EMT in NSCLC cells in vitro.CircZCCHC6 silencing hindered cell growth and EMT of NSCLC in vivo.
Molecular mechanism: The mechanical analysis suggested that circZCCHC6 acted as a sponge of hsa-miR-433-3p to regulate LPCAT1 expression.
Survival: -
Supported No.:
 1
Description:

CircZCCHC6 inhibited the progression of NSCLC cells partly by regulating the miR-433-3p/LPCAT1 axis, implying a promising therapeutic target for the NSCLC treatment.
Other information
Title:

Circular RNA circZCCHC6 contributes to tumorigenesis by regulating LPCAT1 via miR-433-3p in non-small cell lung cancer.

Journal: Clin Exp Med
Published: 2022/1/29
PubMed ID: 35089454