circRNA basic information
circBase ID: hsa_circ_0039569
Name: -
Synonym: Circ_0039569
Host Gene: hsa-miR-133b
 
 
 
Disease basic information
DO ID:
 4450
DO name: renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human RCC cell lines (A498, SW839, ACHN, A704, Caki1), normal cells (HK2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-133b
Biological function: silencing of circ_0039569 suppressed cell proliferation, migration, and invasion, but induced cell apoptosis in RCC cells in vitro and impeded tumor growth in vivo.
Molecular mechanism: circ_0039569 acted as a sponge for hsa-miR-133b to regulate the expression of its target MARCKS.
Survival: -
Supported No.:
 1
Description:

Diminished circ_0039569 restrains the growth and propagation of RCC cells via miR-133b/MARCKS axis, indicating an underlying effective therapeutic target for RCC patients.
Other information
Title:

Circ_0039569 Competes with MARCKS for miR-133b Binding Sites to Promote the Progression of Renal Cell Carcinoma.

Journal: Nephron
Published: 2022/1/28
PubMed ID: 35086110