circRNA basic information
circBase ID: -
Name: hsa_circ_FIG
Synonym: circFIG
Host Gene: hsa-miR-493-5p
 
 
 
Disease basic information
DO ID:
 5041
DO name: esophageal cancer
Disease details: esophageal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal esophageal epithelial cells (HET_1A), EC cell lines (KYSE_410, KYSE_150, Eca_109, EC9706)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-493-5p
Biological function: circFIG 4 knockdown impeded proliferation, migration, and invasion and expedited apoptosis in EC cells.
Molecular mechanism: circFIG 4 modulated E2F3 expression through acting as a sponge of hsa-miR-493-5p.
Survival: -
Supported No.:
 1
Description:

circFIG 4 silence mitigated EC malignant progression at least partly by mediating the miR-493-5p/E2F3 pathway, highlighting new biomarkers and therapeutic targets for EC treatment.
Other information
Title:

circFIG 4 drives the carcinogenesis and metastasis of esophagus cancer via the miR-493-5p/E2F3 axis.

Journal: Thorac Cancer
Published: 2022/1/28
PubMed ID: 35083866