circRNA basic information
circBase ID: -
Name: hsa_circ_PRDM5
Synonym: circ-PRDM5
Host Gene: hsa-miR-92b-3p
 
 
 
Disease basic information
DO ID:
 0070353
DO name: cataract
Disease details: posterior capsule opacification
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human lens epithelial cells SRA01/04 (LECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-92b-3p
Biological function: Both circ-PRDM5 and COL1A2 knockdown impaired TGF-beta2-induced LEC migration, invasion, and EMT.
Molecular mechanism: circ-PRDM5 could adsorb hsa-miR-92b-3p to regulate COL1A2 expression.
Survival: -
Supported No.:
 1
Description:

In summary, TGF-beta2-induced circ-PRDM5 facilitated LEC migration, invasion, and EMT by adsorbing miR-92b-3p and increasing COL1A2 expression, offering new insights into the development of PCO.
Other information
Title:

TGF-beta2-induced circ-PRDM5 regulates migration, invasion, and EMT through the miR-92b-3p/COL1A2 pathway in human lens epithelial cells.

Journal: J Mol Histol
Published: 2022/1/28
PubMed ID: 35083632