circRNA basic information
circBase ID: -
Name: hsa_circ_LPAR3
Synonym: circ-LPAR3
Host Gene: hsa-miR-63
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human OC cell lines (SKOV3, A2780), DDP-resistant OC cell lines (SKOV3/DDP, A2780/DDP), ovarian epithelial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-63
Biological function: Silencing of circ-LPAR3 enhanced the DDP sensitivity of OC cells and tumors.
Molecular mechanism: hsa-miR-634 could interact with circ-LPAR3, and its inhibitor overturned the regulation of si-circ-LPAR3 on cell DDP resistance
Survival: -
Supported No.:
 1
Description:

To sum up, circ-LPAR3 might contribute to the DDP resistance of OC via the miR-634/PDK1 axis.
Other information
Title:

Circular RNA lysophosphatidic acid receptor 3 (circ-LPAR3) enhances the cisplatin resistance of ovarian cancer.

Journal: Bioengineered
Published: 2022/1/28
PubMed ID: 35081867