circRNA basic information
circBase ID: hsa_circ_0033596
Name: -
Synonym: circ_0033596
Host Gene: hsa-miR-217-5p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: cell line
Sample type details: HUVECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-217-5p
Biological function: After ox-LDL stimulation, HUVEC viability and cell cycle progression were inhibited, and the apoptosis was promoted, while circ_0033596 overexpression aggravated these effects.
Molecular mechanism: CLIC4 was identified as hsa-miR-217-5ps downstream target gene and could be positively modulated by circ_0033596.
Survival: -
Supported No.:
 1
Description:

All in all circ_0033596 aggravates ox-LDL-induced HUVEC apoptosis by regulating the miR-217-5p/CLIC4 axis, by which circ_0033596 participates in the pathogenesis of AS.
Other information
Title:

Circular RNA_0033596 aggravates endothelial cell injury induced by oxidized low-density lipoprotein via microRNA-217-5p /chloride intracellular channel 4 axis.

Journal: Bioengineered
Published: 2022/1/28
PubMed ID: 35081862