circRNA basic information
circBase ID: hsa_circ_0040705
Name: -
Synonym: CircRNA_0040705
Host Gene: hsa-miR-557
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: hepatic cell line (L02), HCC cell lines (SNU-475, SNU-182, HepG2, Hep3B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-557
Biological function: circ_0040705 overexpression enhanced the growth, migration, invasion, and the expressions of E-cadherin and N-cadherin of HCC cells and promoted lung metastasis in vivo
Molecular mechanism: Circ_0040705 worked as a sponge for hsa-miR-557 to down-modulate hsa-miR-557 expression, and hsa-miR-557 could specifically down-modulate SOX2 expression.
Survival: -
Supported No.:
 1
Description:

Circ_0040705 facilitates HCC cell growth, migration, and invasion by down-modulating miR-557 expression and up-modulating SOX2 expression.
Other information
Title:

CircRNA_0040705 promotes the progression of hepatocellular carcinoma.

Journal: IUBMB Life
Published: 2022/1/27
PubMed ID: 35080329