circRNA basic information
circBase ID: -
Name: hsa_circ_PRH1-PRR4
Synonym: circPRH1-PRR4
Host Gene: hsa-miR-877-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cell lines (A549, H522), human normal lung epithelial cell (BEAS_2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-877-5p
Biological function: Reduced expression of circPRH1-PRR4 resulted in inhibition of cell proliferation, migration, and invasion, but promotion of cell apoptosis in vitro. In support, circPRH1-PRR4 silencing inhibited tumor formation in vivo.
Molecular mechanism: hsa-miR-877-5p was a target miRNA of circPRH1-PRR4, , RAB3D was identified as a target mRNA of hsa-miR-877-5p.
Survival: -
Supported No.:
 4
Description:

CircPRH1-PRR4 knockdown impeded NSCLC cell malignancy by the miR-877-5p/RAB3D pathway, providing a possible circRNA-targeted therapy for NSCLC.
Other information
Title:

CircRNA PRH1-PRR4 stimulates RAB3D to regulate the malignant progression of NSCLC by sponging miR-877-5p.

Journal: Thorac Cancer
Published: 2022/1/26
PubMed ID: 35076987