circRNA basic information
circBase ID: hsa_circ_0003611
Name: -
Synonym: Circ_0003611
Host Gene: hsa-miR-885-5p
 
 
 
Disease basic information
DO ID:
 10652
DO name: Alzheimer disease
Disease details: Alzheimer disease
Species: human
Species details: human
Sample type: cell line
Sample type details: SK-N-SH cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-885-5p
Biological function: Abeta-induced apoptotic, inflammatory and oxidative damages were relieved after knockdown of circ_0003611.
Molecular mechanism: hsa-miR-885-5p was validated as a miRNA target of circ_0003611. KREMEN1 was a downstream gene of hsa-miR-885-5p.
Survival: -
Supported No.:
 3
Description:

These experimental data demonstrated that circ_0003611 enhanced the Abeta-induced neuronal cell injury in AD by serving as the miR-885-5p sponge to regulate the level of KREMEN1.
Other information
Title:

Circ_0003611 acts as a miR-885-5p sponge to aggravate the amyloid-beta-induced neuronal injury in Alzheimer disease.

Journal: Metab Brain Dis
Published: 2022/1/26
PubMed ID: 35076819